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童德文 
发布时间:2016-04-15  浏览次数:

  一、基本情况

  童德文,男,汉族,安徽省太湖县人,博士,三级教授,博士生导师,现任动医学院副院长,教育部新世纪优秀人才,陕西省重点科技创新团队“畜禽重大疫病新型疫苗研发创新团队”带头人(2013),陕西省教学团队“基础兽医学教学团队” 带头人(2013),陕西省精品资源共享课程“动物病理解剖学”负责人(2014),西北农林科技大学基础兽医学学科带头人。

  二、研究方向

  动物病理学;细胞生理及病理

  三、个人简历

  1994年7月研究生毕业获农学硕士学位并留校从事动物病理学教研工作。

  1996年9月,考取西北农林科技大学临床兽医学专业博士研究生,2001年1月毕业获农学博士学位,同年12月晋升副教授,2002年遴选为硕士生导师。

  2005年被评为西北农林科技大学首批青年学术骨干,同年在新西兰Lincoln University研修。2007年遴选为博士生导师。

  近年来发表科研论文110余篇,获奖科研论文15篇。作为发明人申请了10项发明专利,其中5项已经授权,作为技术负责人和完成人鉴定和验收的科研成果3项。主持霍英东教育基金、国家自然科学基金、国际科学基金(IFS)、高等院校博士点基金和陕西省农业科技创新项目等项目。

  近年来致力于宿主细胞和病原的相互作用研究和动物重大疫病新型疫苗研发。相关研究成果发表于Journal of Biological Chemistry, Veterinary Microbiology,Vaccine,Molecular and Cellular Endocrinology, PLoS One, Theriogenology, International Journal of Biological Science, Journal of General Virology, Virus Research , Journal of Virological Methods, Biochemical and Biophysical Research Communications等期刊,已培养毕业博士生7名、硕士生31名,在读全日制博士生10名、硕士生9名、博士后4名。

  四、代表性论著

  1.   Zhao X, Xiang H, Bai X, Fei N, Huang Y, Song X, Zhang H, Zhang L and Tong D*, Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virol J, 2016. 13(1): p. 26.

  2.   Zhao X, Song X, Bai X, Fei N, Huang Y, Zhao Z, Du Q, Zhang H, Zhang L and Tong D*, miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ, 2016. 4: p. e1635.

  3.   Zhang H, Huang Y, Wang L, Yu T, Wang Z, Chang L, Zhao X, Luo X, Zhang L and Tong D*,Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.

  4.   Li D, Huang Y, Du Q, Wang Z, Chang L, Zhao X and Tong D*, CD40 Ligand and GMCSF Coexpression Enhance the Immune Responses and Protective Efficacy of PCV2 Adenovirus Vaccine. Viral Immunol, 2016. 29(3): p. 148-158.

  5.   Huo R, Wang L, Wang X, Zhao Y, Wang Y, Zhao X, Chang L, Liu SL, Tong D*,  Zhang H and Huang Y, Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice. Oncotarget, 2016.

  6.   Du Q, Huang Y, Wang T, Zhang X, Chen Y, Cui B, Li D, Zhao X, Zhang W, Chang L and Tong D*,Porcine circovirus type 2 activates PI3K/Akt and p38 MAPK pathways to promote interleukin-10 production in macrophages via Cap interaction of gC1qR. Oncotarget, 2016.

  7.   Zhang H, Huang Y, Du Q, Luo X, Zhang L, Zhao X and Tong D*,Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochem Biophys Res Commun, 2015. 456(2): p. 649-655.

  8.   Song X, Zhao X, Huang Y, Xiang H, Zhang W and Tong D*,Transmissible gastroenteritis virus (TGEV) infection alters the expression of cellular microRNA species that affect transcription of TGEV gene 7. Int J Biol Sci, 2015. 11(8): p. 913-922.

  9.   Huang Y, Xing N, Wang Z, Zhang X, Zhao X, Du Q, Chang L and Tong D*,Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR Assay. PLoS One, 2015. 10(11): p. e0141545.

  10. Fan Y, Ren M, Hou W, Guo C, Tong D*, Ma L, Zhang W, He M and Song X*, The activation of Epimedium polysaccharide-propolis flavone liposome on Kupffer cells. Carbohydr Polym, 2015. 133: p. 613-623.

  11. Fan Y, Ma X, Zhang J, Ma L, Gao Y, Zhang W, Song X*, Hou W, Guo C and Tong D*,Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydr Polym, 2015. 119: p. 219-227.

  12. Wang J, Song L, Zhang Q, Zhang W, An L, Zhang Y, Tong D, Zhao B, Chen S and Zhao S*, Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory. Toxicol Lett, 2014. 232(1): p. 263-270.

  13. Li W, Huang Y, Zhao X, Zhang W, Dong F, Du Q and Tong D*,Swainsonine induces caprine luteal cells apoptosis via mitochondrial-mediated caspase-dependent pathway. J Biochem Mol Toxicol, 2014. 28(10): p. 456-464.

  14. Huang Y, Zhang X, Du Q, Wang F, Zhao X, Zhang W and Tong D*,Preclinical detection of porcine circovirus type 2 infection using an ultrasensitive nanoparticle DNA probe-based PCR assay. PLoS One, 2014. 9(5): p. e97869.

  15. Huang Y, Dong F, Du Q, Zhang H, Luo X, Song X, Zhao X, Zhang W and Tong D*,Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. Int J Biol Sci, 2014. 10(7): p. 789-797.

  16. Fan Y, Song X, Gao Y, Chen Y, Ma L, Zhang W, Hou W, Guo C and Tong D*,Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. Int J Pharm, 2014. 477(1-2): p. 421-430.

  17. Ding L, Huang Y, Du Q, Dong F, Zhao X, Zhang W, Xu X and Tong D*,TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochem Biophys Res Commun, 2014. 445(2): p. 497-503.

  18. Zhang W, Yu G, Huang Y, Xu D, Ren J, Jiang L, Wu C and Tong D*,Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro. Mol Cell Endocrinol, 2013. 370(1-2): p. 20-31.

  19. Xu X, Zhang H, Zhang Q, Huang Y, Dong J, Liang Y, Liu HJ* and Tong D*,Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Vet Microbiol, 2013. 164(3-4): p. 212-221.

  20. Xu X, Zhang H, Zhang Q, Dong J, Liang Y, Huang Y, Liu HJ* and Tong D*,Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virol J, 2013. 10: p. 26.

  21. Huang Y, Shao M, Xu X, Zhang X, Du Q, Zhao X, Zhang W, Lyu Y and Tong D*,Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Res, 2013. 175(1): p. 78-86.

  22. Huang Y, Li W, Zhao X, Ding L, Yu G, Dong F, Du Q, Xu X and Tong D*,Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology, 2013. 80(1): p. 41-49.

  23. Huang Y, Ding L, Li Z, Dai M, Zhao X, Li W, Du Q, Xu X and Tong D*,Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. J Gen Virol, 2013. 94(Pt 8): p. 1807-1817.

  24. Dong F, Huang Y, Li W, Zhao X, Zhang W, Du Q, Zhang H, Song X and Tong D*,The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta, 2013. 34(12): p. 1243-1250.

  25. Ding L, Zhao X, Huang Y, Du Q, Dong F, Zhang H, Song X, Zhang W and Tong D*,Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochem Biophys Res Commun, 2013. 442(1-2): p. 33-37.

  26. Ding L, Huang Y, Dai M, Zhao X, Du Q, Dong F, Wang L, Huo R, Zhang W, Xu X and Tong D*,Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Res, 2013. 178(2): p. 241-251.

  27. Xu X, Zhao H, Zhang Q, Ding L, Li ZC, Li W, Wu H, Chuang K, Tong D* and Liu H*, Oral vaccination with attenuated Salmonella enterica serovar Typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Vet Microbiol, 2012. 157(3-4): p. 294-303.

  28. Xu X, Wang Z, Zhang Q, Li Z, Ding L, Li W, Wu H, Chang C, Lee LH, Tong D* and Liu H*,Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirus virions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. J Virol Methods, 2012. 179(2): p. 359-366.

  29. Xu X, Chen G, Huang Y, Ding L, Li Z, Chang C, Wang C, Tong D* and Liu H*, Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. J Virol Methods, 2012. 183(1): p. 69-74.

  30. Xu X, Zhang K, Huang Y, Ding L, Chen G, Zhang H and Tong D*,Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virol J, 2012. 9: p. 202.

  31. Li Z, Xu X, Huang Y, Ding L, Wang Z, Yu G, Xu D, Li W and Tong D*,Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. Int J Biol Sci, 2012. 8(3): p. 394-405.

  32. Li Z, Huang Y, Dong F, Li W, Ding L, Yu G, Xu D, Yang Y, Xu X and Tong D*,Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. J Biosci, 2012. 37(6): p. 1005-1016.

  33. Li W, Xu X, Huang Y, Li Z, Yu G, Wang Z, Ding L and Tong D*,Establishment and evaluation of a stable steroidogenic caprine luteal cell line. Theriogenology, 2012. 78(2): p. 263-272.

  34. Ding L, Xu X, Huang Y, Li Z, Zhang K, Chen G, Yu G, Wang Z, Li W and Tong D*,Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Vet Microbiol, 2012. 158(1-2): p. 12-22.

  35. Xu X, Wang Z, Zhang Q, Li Z, Zhao H, Li W, Tong D* and Liu H*, Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine, 2011. 29(4): p. 636-643.

  36. Xu X, Tong D, Wang Z, Zhang Q, Li Z, Zhang K, Li W and Liu H*, Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection. Avian Dis, 2011. 55(2): p. 223-229.

  37. Wang Z, Xu X, Liu H, Li Z, Ding , Yu G and Tong D*,Immunogenicity of the envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus. Acta Virol, 2011. 55(2): p. 139-146.

  38. Xu X, Tong D, Chiou M, Hsieh Y, Shih W, Chang C, Liao M, Zhang Y and Liu H*,Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus. J Virol Methods, 2009. 159(2): p. 259-264.

  39. Wang J*, Wang Q, Ren L, Wang X, Wan Z, Liu W, Li L, Zhao H, Li M, Tong D and Xu J, Carboxylated magnetic microbead-assisted fluoroimmunoassay for early biomarkers of acute myocardial infarction. Colloids Surf B Biointerfaces, 2009. 72(1): p. 112-120.

  40. Wang J*, Ren L, Wang X, Wang Q, Wan Z, Li L, Liu W, Wang X, Li M, Tong D, Liu A and Shang B,Superparamagnetic microsphere-assisted fluoroimmunoassay for rapid assessment of acute myocardial infarction. Biosens Bioelectron, 2009. 24(10): p. 3097-3102.

  41. Wang J*, Ren L, Li L, Liu W, Zhou J, Yu W, Tong D and Chen S, Microfluidics: a new cosset for neurobiology. Lab Chip, 2009. 9(5): p. 644-652.

  42. Tong D*, Mu P, Dong Q, Zhao B, Liu W, Zhao J, Li L, Zhou T, Wang J and Sui G*, Immunological evaluation of SW-HSA conjugate on goats. Colloids Surf B Biointerfaces, 2007. 58(1): p. 61-67.

  五、科研项目

  近年来主持的科研项目:

  1. 国家自然科学基金

  2. 霍英东教育基金

  3. 国际科学基金

  4. 高等院校博士点基金

  5. 转基因生物新品种培育科技重大专项(子项目)

  6. 陕西重点科技攻关项目

  7. 动物重大疫病新型疫苗研发

  六、荣誉及奖项

  教育部新世纪优秀人才;三秦人才。

  七、社会兼职

  中国畜牧兽医学会动物病理学分会常务理事;中国畜牧兽医学会动物毒物学分会常务理事;《动物医学进展》杂志副主编;国家科技奖评审专家;国家自然科学基金评审专家等。

  八、联系方式

  电子邮箱:tdw8888@sina.com

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